The big news from Etihad Stadium is that Erling Haaland is back in the Manchester City squad after his injury but starts the game on the bench.
It total, City make eight changes from the side that beat Seville here on Wednesday, for their 14th successive home win.
Ederson returns in goal and has a completely new back-four in front of him, while Rodri, Kevin de Bruyne and Bernardo Silva return in midfield.
Ilkay Gundogan, Jack Grealish and Julian Alvarez are the only players who started against Seville to keep their place.
Man City XI: Ederson, Stones, Akanji, Ake, Cancelo, Rodri, De Bruyne, Silva, Gundogan, Grealish, Alvarez.
Subs: Ortega, Dias, Haaland, Laporte, Gomez, Mahrez, Foden, Palmer, Lewis
Fulham make three changes from the side that drew with Everton last weekend.
Top scorer Aleksandar Mitrovic is not in the squad so Carlos Vinicius leads their attack. Kenny Tete replaces the suspended Bobby Decordova-Reid at right-back and Harry Wilson is in for the injured Neeskens Kebano.
Fulham XI: Leno, Tete, Ream, Diop, Robinson, Reed, Pereira, Palhinha, Wilson, Willian, Vinicius
Subs: Rodak, Kurzawa, Adarabioyo, Duffy, Cairney, James, Onomah, Mbabu, Harris
